PTEN Signaling pathways in glioblastoma

PTEN signaling pathways in glioblastoma.

Malignant gliomas are the most common primary brain tumor in adults, but the prognosis for patients with these tumors remains poor despite advances in diagnosis and standard therapies such as surgery, radiation therapy, and chemotherapy. Progress in the treatment of gliomas now depends to a great extent on an increased understanding of the biology of these tumors. Recent insights into the biolo...

SnapShot: PTEN Signaling Pathways

Glioblastoma Multiforme Oncogenomics and Signaling Pathways

In the adult population, glioblastoma multiforme is one of the most common primary brain tumors encountered. Unfortunately, this highly malignant tumor represents over 50% of all types of primary central nervous system gliomas. The vast majority of GBMs develops quite rapidly without clinical, radiological, or morphologic evidence of a less malignant precursor lesion (primary or de novo GBMs), ...

Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications

Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent po...

brane in Glioblastoma Contributes to PTEN Inactivation

Downlo blastoma multiforme (GBM) is a severe brain malignancy with limited treatment and dismal prognosis. mor suppressor PTEN, a major inhibitor of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway, is ntly deleted in GBM tumors. PTEN antagonizes PI3K by dephosphorylating PI3K phosphoinositide subat the plasma membrane. The PTEN binding adapter protein NHERF1/EBP50 is overexpressed in GB...